{"id":34095,"date":"2020-02-08T17:03:00","date_gmt":"2020-02-08T23:03:00","guid":{"rendered":"http:\/\/milesfortis.com\/?p=34095"},"modified":"2020-02-08T17:04:48","modified_gmt":"2020-02-08T23:04:48","slug":"34095","status":"publish","type":"post","link":"https:\/\/milesfortis.com\/?p=34095","title":{"rendered":""},"content":{"rendered":"

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus\u2013Infected Pneumonia in Wuhan, China<\/a><\/p>\n

Key Points<\/span><\/p>\n

Question<\/strong>\u00a0\u00a0What are the clinical characteristics of hospitalized patients with 2019 novel coronavirus (2019-nCoV)\u2013infected pneumonia (NCIP) in Wuhan, China?<\/p>\n

Findings<\/strong>\u00a0\u00a0In this single-center case series involving 138 patients with NCIP, 26% of patients required admission to the intensive care unit and 4.3% died. Presumed human-to-human hospital-associated transmission of 2019-nCoV was suspected in 41% of patients.<\/span><\/p>\n

Meaning<\/strong>\u00a0\u00a0In this case series in Wuhan, China, NCIP was frequently associated with presumed hospital-related transmission, 26% of patients required intensive care unit treatment, and mortality was 4.3%.<\/p>\n

\n
Abstract<\/div>\n<\/div>\n

Importance<\/strong>\u00a0\u00a0In December 2019, novel coronavirus (2019-nCoV)\u2013infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.<\/p>\n

Objective<\/strong>\u00a0\u00a0To describe the epidemiological and clinical characteristics of NCIP.<\/p>\n

Design, Setting, and Participants<\/strong>\u00a0\u00a0Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020.<\/p>\n

Exposures<\/strong>\u00a0\u00a0Documented NCIP.<\/p>\n

Main Outcomes and Measures<\/strong>\u00a0\u00a0Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Outcomes of critically ill patients and noncritically ill patients were compared. Presumed hospital-related transmission was suspected if a cluster of health professionals or hospitalized patients in the same wards became infected and a possible source of infection could be tracked.<\/p>\n

Results<\/strong>\u00a0\u00a0Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men. Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]). Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). Lymphopenia (lymphocyte count, 0.8\u2009\u00d7\u2009109<\/sup>\/L [interquartile range {IQR}, 0.6-1.1]) occurred in 97 patients (70.3%), prolonged prothrombin time (13.0 seconds [IQR, 12.3-13.7]) in 80 patients (58%), and elevated lactate dehydrogenase (261 U\/L [IQR, 182-403]) in 55 patients (39.9%). Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients. Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). Thirty-six patients (26.1%) were transferred to the intensive care unit (ICU) because of complications, including acute respiratory distress syndrome (22 [61.1%]), arrhythmia (16 [44.4%]), and shock (11 [30.6%]). The median time from first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to ARDS was 8.0 days. Patients treated in the ICU (n\u2009=\u200936), compared with patients not treated in the ICU (n\u2009=\u2009102), were older (median age, 66 years vs 51 years), were more likely to have underlying comorbidities (26 [72.2%] vs 38 [37.3%]), and were more likely to have dyspnea (23 [63.9%] vs 20 [19.6%]), and anorexia (24 [66.7%] vs 31 [30.4%]). Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). As of February 3, 47 patients (34.1%) were discharged and 6 died (overall mortality, 4.3%), but the remaining patients are still hospitalized. Among those discharged alive (n\u2009=\u200947), the median hospital stay was 10 days (IQR, 7.0-14.0).<\/p>\n

Conclusions and Relevance<\/strong>\u00a0\u00a0In this single-center case series of 138 hospitalized patients with confirmed NCIP in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected in 41% of patients, 26% of patients received ICU care, and mortality was 4.3%.<\/span><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus\u2013Infected Pneumonia in Wuhan, China Key Points Question\u00a0\u00a0What are the clinical characteristics of hospitalized patients with 2019 novel coronavirus (2019-nCoV)\u2013infected pneumonia (NCIP) in Wuhan, China? Findings\u00a0\u00a0In this single-center case series involving 138 patients with NCIP, 26% of patients required admission to the intensive care unit and … Continue reading “”<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-34095","post","type-post","status-publish","format-standard","hentry","category-health-medicine"],"_links":{"self":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/34095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=34095"}],"version-history":[{"count":3,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/34095\/revisions"}],"predecessor-version":[{"id":34098,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/34095\/revisions\/34098"}],"wp:attachment":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=34095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=34095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=34095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}