{"id":65619,"date":"2021-03-09T00:38:13","date_gmt":"2021-03-09T06:38:13","guid":{"rendered":"https:\/\/milesfortis.com\/?p=65619"},"modified":"2021-03-09T00:38:13","modified_gmt":"2021-03-09T06:38:13","slug":"65619","status":"publish","type":"post","link":"https:\/\/milesfortis.com\/?p=65619","title":{"rendered":""},"content":{"rendered":"<p><a href=\"https:\/\/www.nature.com\/articles\/s41598-020-77093-z\" target=\"_blank\" rel=\"noopener\">Analysis of Vitamin D Level Among Asymptomatic and Critically Ill COVID-19 Patients and Its Correlation With Inflammatory Markers<\/a><\/p>\n<p>Abstract<\/p>\n<p>COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the vitamin D level in COVID-19 patients and its impact on the disease severity. After approval from Ethics Committee, M.L.B Medical College the current study was undertaken as continuous prospective observational study of 6 weeks.<\/p>\n<p>Participants were COVID-19 patients of age group 30-60 years admitted during the study period of 6 weeks. Study included either asymptomatic COVID-19 patients (Group A) or severely ill patients requiring ICU admission (Group B). Serum concentration of 25 (OH)D, were measured along with serum IL-6; TNF? and serum ferritin. Standard statistical analysis was performed to analyze the differences. Current Study enrolled 154 patients, 91 in Group A and 63 patients in Group B. The mean level of vitamin D (in ng\/mL) was 27.89 \u00b1 6.21 in Group A and 14.35 \u00b1 5.79 in Group B, the difference was highly significant.<\/p>\n<p>The prevalence of vitamin D deficiency was 32.96% and 96.82% respectively in Group A and Group B. Out of total 154 patients, 90 patients were found to be deficient in vitamin D (Group A: 29; Group B: 61). Serum level of inflammatory markers was found to be higher in vitamin D deficient COVID-19 patients viz. IL-6 level (in pg\/mL) 19.34 \u00b1 6.17 vs 12.18 \u00b1 4.29; Serum ferritin 319.17 \u00b1 38.21 ng\/mL vs 186.83 \u00b1 20.18 ng\/mL; TNF? level (in pg\/mL) 13.26 \u00b1 5.64 vs 11.87 \u00b1 3.15. The fatality rate was high in vitamin D deficient (21% vs 3.1%).<\/p>\n<p><strong>Vitamin D level is markedly low in severe COVID-19 patients. Inflammatory response is high in vitamin D deficient COVID-19 patients. This all translates into increased mortality in vitamin D deficient COVID-19 patients. As per the flexible approach in the current COVID-19 pandemic authors recommend mass administration of vitamin D supplements to population at risk for COVID-19.<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Analysis of Vitamin D Level Among Asymptomatic and Critically Ill COVID-19 Patients and Its Correlation With Inflammatory Markers Abstract COVID-19 is characterized by marked variability in clinical severity. Vitamin D had recently been reviewed as one of the factors that may affect the severity in COVID-19. The objective of current study is to analyze the &hellip; <a href=\"https:\/\/milesfortis.com\/?p=65619\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-65619","post","type-post","status-publish","format-standard","hentry","category-health-medicine"],"_links":{"self":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/65619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=65619"}],"version-history":[{"count":1,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/65619\/revisions"}],"predecessor-version":[{"id":65620,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/65619\/revisions\/65620"}],"wp:attachment":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=65619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=65619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=65619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}