{"id":80176,"date":"2022-04-19T13:08:25","date_gmt":"2022-04-19T18:08:25","guid":{"rendered":"https:\/\/milesfortis.com\/?p=80176"},"modified":"2022-04-19T13:08:25","modified_gmt":"2022-04-19T18:08:25","slug":"80176","status":"publish","type":"post","link":"https:\/\/milesfortis.com\/?p=80176","title":{"rendered":""},"content":{"rendered":"<p>I hate holding the &#8216;key&#8217; anything. Been there, done that, got the T shirt, wore it out and turned it into a rag.<\/p>\n<hr \/>\n<p><a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2022-03-30\/never-had-covid-you-may-hold-key-to-beating-the-virus\">Never Had Covid? You May Hold The Key To Beating The Virus.<\/a><\/p>\n<p><a href=\"https:\/\/covid.cdc.gov\/covid-data-tracker\/#national-lab\" target=\"_blank\" rel=\"noopener\">More than half<\/a>\u00a0of Americans may have never had Covid, according to U.S. government data, leaving scientists wondering whether those who\u2019ve avoided the novel coronavirus might actually be immune to the virus altogether. This could offer new clues into how to attack\u00a0Covid.<\/p>\n<p>At this stage in the pandemic, people may be immune due to vaccines, a past infection, or a combination of both. There\u2019s also\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-021-04186-8#\" target=\"_blank\" rel=\"noopener\">evidence<\/a>\u00a0that, in rare instances, some people may be Covid-immune without infection or vaccination at all.<\/p>\n<aside class=\"postr-recirc postr-recirc--prognosis paywall\">\n<div class=\"postr-recirc__container\">\n<div class=\"postr-recirc__story\">\n<div class=\"postr-recirc__story-headline\">The coronavirus\u2019s frequent mutations and the fact that immunity wanes over time make it difficult to discern how many people are immune at any given moment.\u00a0 Studies have shown, for example, that while omicron infections offer some <a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2021-12-28\/omicron-may-reduce-delta-infections-south-african-study-shows\" target=\"_blank\" rel=\"noopener\">immunity against delta<\/a>, omicron is able to circumvent antibodies from both past infection with other variants and vaccination. Current surveillance techniques have also likely vastly underestimated the number of cases, as more people are taking Covid tests at home and not reporting the results.<\/div>\n<\/div>\n<\/div>\n<\/aside>\n<p class=\"paywall\">\n&#8220;It&#8217;s nearly impossible to gauge protection,&#8221; said Andy Pekosz, a virologist at Johns Hopkins Bloomberg School of Public Health.<\/p>\n<p>As cases yet again rise in many regions more than two years into the pandemic, studying those who have not yet caught Covid has become just as critical as studying those who have. Experts say that people with so-called \u201csuper\u201d immunity who appear resistant to the virus without vaccination may hold answers to important questions about why certain people get so sick while others don\u2019t. Examining these cases\u00a0could also help inform the development of\u00a0vaccines and\u00a0therapeutics less vulnerable to viral mutations.<\/p>\n<p>\u201cIt is essentially defining what a best-case scenario looks like, which can also help to identify what is going wrong in those that don\u2019t control the virus,\u201d said Leo Swadling, an immunologist at the University College of London.<\/p>\n<p class=\"paywall\">It may be hard to believe that at this stage of the pandemic\u00a0so many people have still never gotten sick. Perhaps people were asymptomatic and never knew they were infected, or, despite exposure to the virus, they just never tested positive. But even half of the population getting Covid is actually an extraordinary number of infections. The 1918 Spanish flu is\u00a0<a href=\"https:\/\/www.archives.gov\/exhibits\/influenza-epidemic\/\" target=\"_blank\" rel=\"noopener\">estimated<\/a>\u00a0to have only infected 25% of the U.S. population at the time, despite causing a huge number of deaths.<\/p>\n<p>Early in the pandemic, Swadling set out to find out more about the lucky few who weren\u2019t getting sick.<\/p>\n<p class=\"paywall\"><!--more--><\/p>\n<p>\u201cWe were particularly interested in people who are exposed to the virus, but control it very quickly, clearing the virus before it can replicate to detectable levels and before it induces an antibody response,\u201d Swadling said. \u201cIt may help us better understand what immunity is best at protection from reinfection.\u201d<\/p>\n<p>Swadling, along with colleagues in London, published a\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-021-04186-8#\" target=\"_blank\" rel=\"noopener\">study<\/a>\u00a0in the journal Nature last November evaluating a group of U.K. health care workers during the first wave of the pandemic. They found evidence that some of the health care workers exposed to the virus were able to rid their bodies of it even before producing Covid-specific antibodies.<\/p>\n<p>It turned out that for those people, exposure to other human coronaviruses, such as those that cause cold-like symptoms, had helped their bodies to fight off the novel coronavirus. This is because\u00a0<a href=\"https:\/\/www.cdc.gov\/vaccines\/acip\/meetings\/downloads\/slides-2021-09-22\/03-COVID-Thornburg-508.pdf\" target=\"_blank\" rel=\"noopener\">T-cells<\/a>, a critical part of the body\u2019s immune response, were able to recognize and target genetic elements of prior seasonal coronaviruses that also happened to be present in SARS-CoV-2.\u00a0 That meant their bodies were able to attack the novel virus without the production of new antibodies specific to it.<\/p>\n<p>Notably, the T-cells that those health care workers produced targeted a different part of the virus than the T-cells did in people who have a detectable Covid infection.\u00a0Swadling said the while\u00a0the T-cells produced by both vaccines and a detectable Covid-19 infection attack the frequently mutating spike protein\u00a0of a virus, these health care workers\u2019 T-cells instead targeted\u00a0the virus\u2019 internal machinery.\u00a0Researchers call\u00a0these T-cells that appear effective against different coronaviruses\u00a0\u201ccross-reactive.\u201d<\/p>\n<p>\u201cWe identified new parts of the virus that we can put into a vaccine to try to improve it ,\u201d Swadling said. These improvements, he said, could make vaccines better at preventing\u00a0infection, more effective against new variants and more protective for\u00a0immunocompromised individuals.<\/p>\n<figure class=\"figure-expandable paywall\" data-align=\"center\" data-id=\"385845684\" data-image-size=\"column\" data-image-type=\"photo\" data-type=\"image\">\n<div class=\"image figure-expandable-image__b21aa779\" tabindex=\"0\" role=\"button\" aria-label=\"Open image in viewer\"><\/div><figcaption>\n<div class=\"news-figure-credit credit\">Immunity to a virus occurs when the body is able to recognize a pathogen and effectively fend off infection or disease. Antibodies, such as those acquired from a vaccine or previous infection, attack a virus as soon as it enters the body. T-cells act as another line of defense, working to stop the spread of infection and development of disease once the virus has made it into the body. The mRNA vaccines such as those made by Pfizer and Moderna work by training the body to safely produce antibodies without infection, but they also spur the production of T-cells and B-cells. That\u2019s why the vaccines effectively prevent hospitalization even when they don\u2019t prevent infection altogether \u2014 even when antibodies have waned, T-cells are still there to help fight off an infection more quickly.<\/div>\n<\/figcaption><\/figure>\n<p class=\"paywall\">\nThe study\u2019s authors proposed that T-cells they found\u2014 the ones that target the virus\u2019 internal machinery\u2014 may offer better protection against emerging variants because of their ability to attack a key part of the virus less vulnerable to mutations than its spike protein. They theorize that targeting those areas of the virus could make the shots more effective.<\/p>\n<p>As labs work to\u00a0<a href=\"https:\/\/www.bloomberg.com\/news\/features\/2021-12-09\/could-a-one-shot-coronavirus-vaccine-protect-you-from-all-variants\" target=\"_blank\" rel=\"noopener\">develop a single shot<\/a>\u00a0that would offer broader protection against any Covid variant, at least one company,\u00a0Gritstone Bio Inc., is looking to put Swadling\u2019s theories to the test.\u00a0Others have reached similar conclusions as Swadling and his colleagues. One\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35013199\/\" target=\"_blank\" rel=\"noopener\">study<\/a>\u00a0found that in households where some people remained Covid-free despite exposure, those people\u00a0also appeared protected by T-cells from past exposure to coronaviruses. Another\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34937928\/\" target=\"_blank\" rel=\"noopener\">study<\/a>\u00a0from January found that some\u00a0<a href=\"https:\/\/www.bloomberg.com\/news\/articles\/2022-02-15\/what-experts-know-about-children-covid-and-omicron-quicktake?srnd=prognosis\" target=\"_blank\" rel=\"noopener\">children<\/a>\u00a0who did not develop Covid antibodies also had cross-reactive T-cells, which may be part of the reason why children generally\u00a0have milder symptoms.<\/p>\n<p>Knowing how many people have this heightened immune response is extremely difficult to assess. Some people may have managed to avoid the virus through continued caution or simply\u00a0luck. But perhaps more important than knowing how many people fall into this category\u00a0is the information about immunity that can be gathered from studying what sets them apart.<\/p>\n<p>\u201cT-cells are very long-lived so we may not need repeated vaccination,\u201d Swadling said.<\/p>\n<p>Studying the super-immune, he said,\u00a0may help us against omicron \u2014 and any future variants of concern.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I hate holding the &#8216;key&#8217; anything. Been there, done that, got the T shirt, wore it out and turned it into a rag. Never Had Covid? You May Hold The Key To Beating The Virus. More than half\u00a0of Americans may have never had Covid, according to U.S. government data, leaving scientists wondering whether those who\u2019ve &hellip; <a href=\"https:\/\/milesfortis.com\/?p=80176\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-80176","post","type-post","status-publish","format-standard","hentry","category-health-medicine"],"_links":{"self":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/80176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=80176"}],"version-history":[{"count":1,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/80176\/revisions"}],"predecessor-version":[{"id":80177,"href":"https:\/\/milesfortis.com\/index.php?rest_route=\/wp\/v2\/posts\/80176\/revisions\/80177"}],"wp:attachment":[{"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=80176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=80176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/milesfortis.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=80176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}