Could Scientists ‘Hack’ the Zika Virus to Kill Brain Cancer?

I seem to remember a disaster movie starring Will Smith……….
and a re-engineered virus that cured cancer……..

The mosquito-spread Zika virus known for its links to brain damage in babies born to infected mothers has the potential to target and destroy brain cancer, scientists have found.

New research has revealed that the Zika virus breaks into brain cells by using a special molecular key, and scientists think the virus could be tweaked so that it infects only brain cancer cells, leaving  healthy cells unharmed.

The aggressive brain cancer glioblastoma often defies standard cancer treatment because the disease transforms normal brain cells into stem cells. While typical neurons stop dividing after so many replications, stem cells can reproduce indefinitely and grow a whole new tumor from just a handful of cells. Patients typically survive less than 20 months after being diagnosed with glioblastoma; even if the cancer can be forced into remission, the tumors typically regrow and take the life of the patient within 12 months.

But where standard treatments fail, the Zika virus may offer a new strategy to wipe out the deadly disease, according to a pair of studies published Jan. 16 in the journals Cell Reports and Cell Stem Cell.

“While we would likely need to modify the normal Zika virus to make it safer to treat brain tumors, we may also be able to take advantage of the mechanisms the virus uses to destroy cells to improve the way we treat glioblastoma,” senior author Dr. Jeremy Rich, director of neuro-oncology and of the Brain Tumor Institute at UC San Diego Health, said in a statement. (Rich and his colleagues authored the Cell Stem Cell paper.)